news: ways to enhance cancer cell death through apoptosis

The Foulger group published an article in Biomaterials Science that presented a general strategy for enhancing apoptosis in cancer cells by reducing "survivin", a member of the family of inhibitor of apoptosis proteins (IAP). To do this, sub-100 nm poly(propargyl acrylate) (PA) particles were surface modified through the copper-catalyzed azide/alkyne cycloaddition of an azide-terminated survivin ligand derivative (azTM) originally proposed by Abbott Laboratories and speculated to bind directly to survivin (protein) at its dimer interface. Using affinity pull-down studies, it was determined that the PA/azTM nanoparticles selectively bind survivin and the particles can enhance apoptotic cell death in glioblastoma cell lines and other survivin over-expressing cell lines, such as A549 and MCF7, relative to cells incubated with the original Abbott-derived small molecule inhibitor.